Lipoprotein lipase responds similarly to tinzaparin as to conventional heparin during hemodialysis
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چکیده
منابع مشابه
Lipoprotein lipase responds similarly to tinzaparin as to conventional heparin during hemodialysis
BACKGROUND Low molecular weight (LMW) heparins are used for anticoagulation during hemodialysis (HD). Studies in animals have shown that LMW-heparins release lipoprotein lipase (LPL) as efficiently as unfractionated (UF) heparin, but are less able to retard hepatic uptake of the lipase. This raises a concern that the LPL system may become exhausted by LMW-heparin in patients on HD. We have expl...
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In the first paper of this series (l), evidence was presented which demonstrates that the clearing factor which appears in postheparin plasma is present in the hearts of normal, non-heparinized rats. This strongly supports the view that the enzyme functions in normal fat metabolism. In this paper, the substrate specificity of lipoprotein lipase is defined, the conversion of coconut oil into an ...
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IN ADDITION to its anticoagulant action, heparin initiates the release of lipoprotein lipase into the blood. This lipolytic enzyme has the capacity to reduce the turbidity of lipemic plasma and hence has become known also as "clearing factor." Its clearing action occurs from the hydrolysis of triglyceride contained in chylomicrons and other lipoprotein particles.' Studies in animals have sugges...
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Some or most of the turnover of lipoprotein lipase (LPL) occurs by dissociation from vascular endothelial sites in extrahepatic tissues and further degradation in the liver. Heparin greatly enhances this dissociation and delays but does not abolish uptake in the liver, raising the possibility that heparin could lead to accelerated catabolism of functional LPL. To investigate this, we determined...
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Division of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan* Division of Nephrology, Chung Shan Medical University Hospital, Taichung, Taiwan** Department of Biotechnology, Hung Kuang University***, Department of Life Science, Tunghai University**** Received: July, 2004 Revised: April, 2005 Accepted: June, 2005 Address reprint requests to Dr. Ku...
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ژورنال
عنوان ژورنال: BMC Nephrology
سال: 2010
ISSN: 1471-2369
DOI: 10.1186/1471-2369-11-33